Abstract: A field experiment was conducted to study the effect of different amounts of additives (humic acid, active calcium and trace elements) on the growth of winter wheat in mild saline-alkali soil. The results showed that the addition of level 1 of trace elements could significantly enhance the tillering ability of wheat, and the addition of level 0 and level 1 of active calcium also had positive effects on it. Level 1 of humic acid and active calcium could significantly increase plant height of wheat; the addition of humic acid could increase the chlorophyll content in the early stage of wheat growth. The addition of humic acid, active calcium and trace elements could increase the biomass of wheat, but had no significant effect on the 1000-grain weight of wheat. Adding high amount of humic acid and trace elements could significantly increase the yield of wheat, while the effect of active calcium was better in low application amount. In this study, level 2 of humic acid, level 0 of active calcium and level 1 of trace elements could increase the yield by 36% and had the best economic benefit, then was level 2 of humic acid, level 1 of active calcium and level 1 of trace elements, which increased the yield by 30.4%. Therefore, under this condition, level 2 of humic acid and level 1 of trace elements were recommended in wheat fertilizer formula, which could ensure high yield of wheat and maintain reasonable fertilizer input.