Abstract: Objective: The iron-carbon micro-electrolysis was prepared to treat the pesticide sewage and the process was optimized. Methods: Preparing the iron-carbon micro-electrolysis under condition of different Fe/C mass ratio、pH and the reaction time to perform single factor experiment. On the basis of single-factor test the three factors of Box-Benhnken experimental design was determined to optimize the processing condition. Results: The optimization analysis shown that the optimal process parameters were as follows: the Fe/C mass ratio was 1:1, pH was 3, reaction times was 1.5h the extraction removal rate of COD was 738%,the relative removal rate of COD the relative standard deviation was 0.11%. Conclusion: The iron-carbon micro-electrolysis method is operation,low in cost and energy efficient which is a good method to treat the pesticide sewage.