Abstract: Poverty alleviation by E-commerce is an important way of accurate poverty alleviation. The authors took Weining County of Guizhou Province as the research object, analyzed the key constraints in the development of E-commerce based on the status of local E-commerce, and put forward the policy measures to promote the development of E- commerce in Weining. Interviewing method, SWOT analysis and analytic hierarchy process were applied in this research, the current situation and problems of E-commerce in Weining were expounded and the internal and external factors were analyzed, strength, weakness, opportunities and threats in agricultural products network marketing were discussed, and by means of experts grading and AHP analysis, the weight of the above factors was calculated, and the strategies of E-commerce development were proposed. The results showed that the development of E-commerce was conducive to poverty alleviation, but the imbalance of purchase and sale was an important and inevitable obstacle. To overcome the obstacle, the factor of threats should be viewed as the biggest impact factor, followed by strength, and the third and fourth were opportunity and weakness. ST strategy could be chosen to promote the agricultural products network marketing in Weining, and the advantages of strength could be taken to resist threats, while taking SO strategy into account. Finally, there were several specific measures as follows: building“green brand”, reducing production and circulation costs; creating a better environment of E-commerce; promoting the service system and developing online tourism business.