Abstract: The paper aims to solve increasingly severe agricultural non-point source pollution (ANSP) problems in Xinjiang to promote its new rural construction and agricultural sustainable development, the paper firstly introduced Xinjiang cotton cultivation region’s general situation, so as to have an acquaintance about cotton production status in Xinjiang, and then through analysis on current situations and problems of non-point source pollution of cotton production in Xinjiang economy and society development process, conducted an analysis on every theoretical models for Xinjiang ANSP control to find out the best control model for Xinjiang, and lastly proposed relevant strategies and suggestions for ANSP control.