Abstract: To analyze the quality of homebrew wine, the physical and chemical indicators and hygienic indicators of 22 samples of homebrew wine are studied. The results showed that only 11 samples of homebrew wines’content of alcohol reached the national standard, the rate was 50%; the content of total sugar of 18 samples was less than or equal to 4.0 g/L, belonging to dry wine; the content of titratable acid of 15 samples was more than 5.0 g/L; the volatile acid content of 4 samples was more with national standards(>1.05 g/L); the methanol content of 8 samples exceeded the national standard(>0.04 g/100 mL); the coliform colonies of 5 samples were out of limits. Comprehensive analysis of the 22 samples show that the quality of 4 samples reaches the national standards, the non-qualified ratio of homebrew wine is as high as 81.81%. Therefore, drinking and brewing of homebrew wine should be careful.