Abstract: The paper aims to reveal the economic development of Gansu. We took a total of 87 regions (86 counties and Jiayuguan) in Gansu as the research unit and selected 12 related indexes, including the per capita GDP, the proportion of the second industry and proportion of the third industry and so on, to establish a comprehensive evaluation system of the county economic development level, and evaluated the economic development level of every region in Gansu during 1995-2015 from the aspects of time and space by using the methods of entropy TOPSIS and ESDA. The results showed that: from 1995 to 2015, the economy of Gansu increased significantly, but it was still in a slow development stage compared with the level of economic development across the country; the differences of the county economy in Gansu was obvious, the top and bottom counties did not change significantly during 1995-2015, Lanzhou and Hexi area had a higher level of development, county development level was low in Longzhong and Longnan, the pattern was“strong constant strong, weak constant weak”; the spatial autocorrelation was significant and the low value clustering was more significant; the hotspot analysis showed that: the county economy of Gansu had obvious monocular economic spatial structure, and the area with high development level had little effect on the surrounding cities, and the regional difference was obvious.