Abstract: Studying the adaptability of Lycium barbarum L. in alpine areas has an important economic and practical value to its popularization and application. We selected the 1300 m2 planting site of Lycium barbarum L. in Qaidam alpine area, based on 3 years’continuous observation of the development period, yield factors and yield structure of Lycium barbarum L., to study the adaptability of Lycium barbarum L. in alpine area in combination with local meteorological data. The results showed that: the development time of Lycium barbarum L. in Qaidam alpine area was 181 days with an average yield of 426.52 g/m2, and the yield structure was: old eye fruit＞summer fruit＞autumn fruit; Pearson correlation showed that the yield of Lycium barbarum L. had no significant correlation with meteorological factors (P>0.05), suggesting that the yield was mainly driven by irrigation. Therefore, Lycium barbarum L. has a good adaptability in Qaidam alpine area and the production needs reasonable management.