Abstract: To screen new multifunctional pesticides which are sustained-release, long-lasting, low-toxic and low-risk to control sugarcane borer and woolly aphid, and explore their accurate and efficient application technology, 10% monosultap·thiamethoxam GR and 1% Bt·clothianidin GR were used for root application in field efficacy trials. The results showed that 10% monosultap·thiamethoxam GR and 1% Bt·clothianidin GR had good control effect on sugarcane borer and woolly aphid, they were new multifunctional pesticides of ideal sustained-release, long-lasting, low-toxin and low-risk, and could used with other pesticides alternately to delay the generation and development of the resistance of pesticides. The optimum dosage of these two pesticides were both 45 kg/hm2. Combined with the sugarcane new planting and ratoon management or‘hilled up’soil between January and July, these two pesticides (45 kg/hm2) were mixed with regular fertilizer (1200-1800 kg/hm2) and applied one time in the sugarcane furrow, stump and the base of stalk, then covered with soil or whole plastic-film mulching. The control effect on borer-damaged dead heart seedling and woolly aphid could be more than 79.2% and 98.8%, respectively. The real yield and sucrose content increased by more than 41555 kg/hm2 and 6.5% compared with that in blank control respectively. These new multifunctional pesticides of sustained-release and long-lasting, which are mixed with base fertilizer and applied in the root one time, are convenient, accurate and effiefficient, labor and time saving, and environment friendly, and could be applied in sugarcane production region.