Abstract: To effectively prevent and control sweet potato stem rot, on the basis of the test in 2016, different concentrations of five fungicides or the mixtures of two of the five fungicides were used in field control experiments on sweet potato stem rot in 2017. The results showed that 50% carbendazim 100 times solution was used for soaking the seedlings before cutting, and then applied to the base of the seedlings after cutting, under the cutting from mid-May to early June, the best control effect could be achieved by 3 times continuous spraying with 10 days interval at the stem base from no sweet potato stem base rot to the onset of the disease. The control effect could reach 60.10%, and the yield was up to 18798.61 kg/hm2, which increased by 389.51% compared with the control and was significantly higher than other treatments.