Abstract: The objective is to breed new wheat variety with high and stable yield, fine quality, strong resistance and wide adaptability. The hybridization test with female parent‘Ji 935-352’and male parent‘Jinan 17’was conducted. The artificial alternate selection was done in different places where soil and production conditions were different. Under the condition of sufficient fertilizer, the wheat were supplied with sufficient water at the early stage to promote the vegetative growth, and then the wheat were grown under drought stress at the later stage for screening high production capacity materials to improve the drought resistance, water saving, stress resistance and adaptability. The selection was focused on the individuals with excellent coordination of production factors. The high- yield lines were identified and screened by cross- regional and multi- point adaptability screening method to select the variety with high and stable yield combining with stress resistance and wide adaptability. At the same time, the quality selection was conducted in the laboratory from F3 generation. A new wheat variety‘Shiyou 20’was bred successfully.‘Shiyou 20’with high yield, high quality, drought resistance, fertilizer tolerance and water saving was authorized by Hebei Provincial Variety Approval Committee in 2009, and then it was authorized by National Variety Approval Committee in 2011.‘Shiyou20’ has rich genetic basis and good traits, thus it can be used as high yield and high quality germplasm.