Current Research Status and Development Trends of Astragalus membranaceus Based on Visual Mapping Analysis with VOSviewer and CiteSpace

doi:10.11924/j.issn.1000-6850.casb2024-0658

Abstract

Abstract:

Based on VOSviewer and CiteSpace, the research hotspots and trends in the field of Astragalus membranaceus research at domestic and international level were explored. Chinese and English literature on Astragalus membranaceus related studies published in the core collections of China National Knowledge Internet (CNKI), Wanfang, Vipshop(VIP) and Web of Science (WOS) from 2000 to 2023 were collected. VOSviewer was used to draw the author cooperation network and the scientific knowledge map of keyword co-occurrence network in Chinese and English literature, and CiteSpace was used to draw the publication journal, publication institution, keyword clustering, keyword timeline and keyword emergence map. A total of 8602 articles were included, including 8089 articles in Chinese and 513 articles in English. The authors with the highest number of publications in both Chinese and English are Qin Xuemei (Modern Research Center of Traditional Chinese Medicine, Shanxi University) and Liu Ping (Capital Medical University). Among the issuing institutions, Beijing University of Traditional Chinese Medicine tops the list in terms of the number of articles issued in Chinese, while Shanghai University of Traditional Chinese Medicine and Nanjing University of Traditional Chinese Medicine are the institutions with the highest number of articles issued in English. The English and Chinese journals with the largest number of articles on Astragalus membranaceus are Lishizhen Medicine and Materia Medica Research and Journal of Ethnopharmacology, respectively. Analysis of the keywords reveals that the main research direction of Astragalus focuses on the composition of Astragalus membranaceus, chemical composition, extraction process, mechanism of action, pharmacological effects, etc. Astragalus membranaceus annual publication volume shows a general trend of growth, with Beijing University of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine, Shanxi University Modern Research Centre of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine and Nanjing University of Traditional Chinese Medicine as the main colleges and universities, research institutions, researchers have carried out a large number of studies on Astragalus membranaceus. In recent years, the emergence of data mining, network pharmacology and molecular docking-based methods to reveal the pharmacological mechanisms of Astragalus membranaceus and classical formulas in disease resistance has become a research hotspot, in addition to the mechanism of action between Astragalus membranaceus actives and intestinal flora will be a research trend in the future research.

Key words: Astragalus membranaceus, VOSviewer, CiteSpace, visual analysis, hotspot analysis

HU Lizhe, ZHANG Bo, HU Danling, DAI Xiaofeng, CHEN Jieyin, SUN Yongwei, KONG Zhiqiang. Current Research Status and Development Trends of Astragalus membranaceus Based on Visual Mapping Analysis with VOSviewer and CiteSpace[J]. Chinese Agricultural Science Bulletin, 2025, 41(14): 137-148.

Figures/Tables 12

References 62

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聚类名称	节点数	轮廓值	年份	主要关键词(LLR)
#0黄芪甲苷	49	0.894	2009	黄芪甲苷；黄芪；凋亡；大鼠；细胞凋亡
#1当归	43	0.772	2007	当归；党参；芒柄花素；质量标准；黄芪多糖
#2蒙古黄芪	40	0.784	2009	蒙古黄芪；多糖；正交实验；含量测定；总皂苷
#3黄芪	39	0.851	2005	黄芪；治疗；黄芪多糖；黄芪甲苷；心肌炎
#4黄芪多糖	33	0.822	2009	黄芪多糖；黄芪；生长性能；免疫功能；免疫调节
#5丹参	28	0.752	2007	丹参；补气药；滋养细胞；儿科药学杂志；心血管疾病
#6小鼠	22	0.791	2005	小鼠；疾病模型；动物；免疫；细胞
#7网络药理学	17	0.749	2018	网络药理学；作用机制；分子对接；信号通路；机制

聚类名称	节点数	轮廓值	年份	主要关键词(LLR)
#0黄芪甲苷	49	0.894	2009	黄芪甲苷；黄芪；凋亡；大鼠；细胞凋亡
#1当归	43	0.772	2007	当归；党参；芒柄花素；质量标准；黄芪多糖
#2蒙古黄芪	40	0.784	2009	蒙古黄芪；多糖；正交实验；含量测定；总皂苷
#3黄芪	39	0.851	2005	黄芪；治疗；黄芪多糖；黄芪甲苷；心肌炎
#4黄芪多糖	33	0.822	2009	黄芪多糖；黄芪；生长性能；免疫功能；免疫调节
#5丹参	28	0.752	2007	丹参；补气药；滋养细胞；儿科药学杂志；心血管疾病
#6小鼠	22	0.791	2005	小鼠；疾病模型；动物；免疫；细胞
#7网络药理学	17	0.749	2018	网络药理学；作用机制；分子对接；信号通路；机制

聚类名称	节点数	轮廓值	年份	主要关键词(LLR)
#0 astragaloside iv	43	0.689	2013	astragaloside iv; oxidative stress; astragalus polysaccharide; inflammation; cardiac hypertrophy
#1 radix astragali	38	0.614	2010	radix astragali; astragali radix; isoflavonoids; hplc; astragaloside
#2 growth performance	22	0.751	2016	growth performance; astragaloside iv; astragalus polysaccharides; gene expression; immune response
#3 molecular docking	21	0.809	2012	molecular docking; network pharmacology; radix astragali; cells; huangqi jianzhong tang
#4 Astragalus membranaceus	19	0.882	2006	Astragalus membranaceus; in vitro; astragaloside iv; systematic review; formononetin
#5 diabetic nephropathy	17	0.725	2011	diabetic nephropathy; injury; blood-brain barrier; db/db mice; huangqi decoction
#6 traditional chinese medicine	17	0.78	2012	traditional chinese medicine; network meta-analysis; angelica sinensis; Astragalus membranaceus var. Mongholicus; signaling pathway
#7 membranaceus bunge	12	0.933	2004	membranaceus bunge; saponin; radix; cycloartane

聚类名称	节点数	轮廓值	年份	主要关键词(LLR)
#0 astragaloside iv	43	0.689	2013	astragaloside iv; oxidative stress; astragalus polysaccharide; inflammation; cardiac hypertrophy
#1 radix astragali	38	0.614	2010	radix astragali; astragali radix; isoflavonoids; hplc; astragaloside
#2 growth performance	22	0.751	2016	growth performance; astragaloside iv; astragalus polysaccharides; gene expression; immune response
#3 molecular docking	21	0.809	2012	molecular docking; network pharmacology; radix astragali; cells; huangqi jianzhong tang
#4 Astragalus membranaceus	19	0.882	2006	Astragalus membranaceus; in vitro; astragaloside iv; systematic review; formononetin
#5 diabetic nephropathy	17	0.725	2011	diabetic nephropathy; injury; blood-brain barrier; db/db mice; huangqi decoction
#6 traditional chinese medicine	17	0.78	2012	traditional chinese medicine; network meta-analysis; angelica sinensis; Astragalus membranaceus var. Mongholicus; signaling pathway
#7 membranaceus bunge	12	0.933	2004	membranaceus bunge; saponin; radix; cycloartane