1  WHO/Unicef/The World Bank,State of the world’s vaccines and immunization 2002,World Heslth Organization Department of Vaccine and Biologicals, Geneva ,2002.95~96 2  Curtiss R I, Carkineau C A. Oral innunization by transgenic plants. World Plant Application,1990,90:107~111 3  庞伟,侯宗柳.转基因植物疫苗研究进展.中国天然药物,2004,2(3):141~144 4  Stephen J, Streatfield, John A. Howard,Plant-based vaccine. International Journal for purasitology, 2003,33:479~493 5  Haq T A, Masson H S, Clements J D, et al. immunization with a recombinant bacrerial antigen produced inransgenic plants. Scinence, 1995, 268:714~716 6  Mason H S, Haq T A, Clements J D, et al. Edible vaccine protects mice against Escherichia coil heat-labile enterotoxin (LT):potatoes  espressing asynthetid LT-B gene. Vaccine, 1998, 16:1336~1343 7  Lauterslager T G M, Florack D E A, et al. Oral immunization of na?ve and primed animals with transgenic potato tubers espressing LT-B. Vaccine, 2001, (19):3661~3670 8  Streatield S J, Jilka J M, et al. Plant-based vaccines: unique advantages. Vaccine,2001,19:2742~2748 9  Streatfield S J, Mayor J M, Barker D K, et al. Development of an edible subunit vaccine in corn against enterotoxigenic strains of Escherichia coli. In Vitro Cell. Dev. Biol. Plant, 2002,38:11~17 10  Arakawa T, Chong D K X, Merritt J L, et al. Expression of cholera toxin B subunit oligomers in transgenic potato plants. Transgenic, 1997,6:403~413 11  Arakawa T, Chong D K X., Langridge W H R. Efficacy of a food plant-based oral cholera toxin B subunit vaccine. Nat. Biotechnol, 1998,16:292~297 12  Daniell H, Lee S B, Panchai T, et al. Expression of the native cholera toxin B subunit gene and assembly of functional oligomers in transgenic tobacco chloroplasts. J. Mol. Biol, 2001,311:1001~1009 13  Jani D, Singh M L., Mohammad Rizwan-ul-Haq Q, et al. Expression of cholera toxin B subunit in transgenic tomato plants. Transgenic Res., 2002,11:447~454 14  Aziz M A, Sikriwal D, Singh S, et al. Transformation of an edible crop with the pagA gene of Bacillus anthracis. FASEB J. 2005 9:1501~1503 15  Richter L J, Thanavala Y, Arntzen C J, et al. Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nat. Biotechnology, 2000,18:1167~1171 16  Kapusta J, Modelska A, Figlerowicz M, et al. A plant-derived edible vaccine against hepatitis B virus. FASEB J, 1999,13:1796~1799 17  Ehsani P, Khabiri A, Domansky N N. Polypeptides of hepatitis B surface antigen produced in transgenic potato. Gene,1997,190:107~111 18  Smith M L, Keegan M E, Mason H S, et al. Factors important in the extraction, stability and in vitro assembly of the hepatitis B surface antigen derived from recombinant plant systems. Biotechnology Progress, 2002,18:538~550 19  Smith M L, Mason H S, Shuler M L. Hepatitis B surface antigen (HbsAg) expression in plant cell culture: kinetics of antigen accumulation in batch culture and its intracellular form. Biotechnol. Bioeng, 2002,80:812~822 20  Nemchinov L G, Liang T J, Rifaat, et al. Development of a plant-derived subunit vaccine candidate against hepatitis C virus. Arch. Virol,2000,145:2557~2573 21  Mason H S, Ball J M, Shi J J, et al.. Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc. Natl Acad. Sci. USA,1996,93:5335~5340 22  Tacket C O, Mason H S, Losonsky, G, et al. Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J. Infect. Dis.,2000,182:302~305 23  Dong JL, Liang BG, Jin YS, et al. Oral immunization with pBsVP6-transgenic alfalfa protects mice against rotavirus infection. Virology. 2005 339(2):153~163 24  Ashraf S, Singh PK, Yadav DK, et al. High level expression of surface glycoprotein of rabies virus in tobacco leaves and its immunoprotective activity in mice. J Biotechnol. 2005 119(1):1~14 25  Yusibov V, Modelska A, Steplewski K, et al. Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1. Proc. Natl Acad. Sci. USA, 1997, 94:5784~5788 26  Yusibov V, Hooper D C, Spitsin S V, et al. Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine. Vaccine, 2002,20:3155~3164 27  Wigdorovitz A, Carrillo C, Dus Santos M J, et al. Induction of a protective antibody response to foot and mouth disease in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viral structural protein VP1. Virology, 1999, 255:347~353 28  Dus Santos M.J., Wigdorovitz A., Trono, K., Rios, R.D, et al. A novel methodology to develop a foot and mouth disease virus (FMDV) peptide-based vaccine in transgenic plants. Vaccine, 2002, 20:1141–1147 29  Usha R, Rohll J B, Spall V E, et al. Expression of an animal virus antigenic site on the surface of a plant virus particle. Virology, 1993,197:366~374 30  Wigdorovitz A, Perez Filgueira D M, et al. Protection of mice against challenge with foot and mouth disease virus (FMDV) by immunization with foliar extracts from plants infected with recombinant tobacco mosaic virus expressing the FMDV structural protein VP1,Virology ,1999,264:85~91 31  Dus Santos MJ, Wigdorovitz A. Expression of foot and mouth disease virus antigens in transgenic plants. Rev Sci Tech,2005,24(1):175~187 32  Gomez N, Wigdorovitz A, Castanon S, et al. Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus. Arch. Virol, 2000,145:1725~1732 33  Tuboly T, Yu W, Bailey A, Degrandis S, et al. Immunogenicity of porcine transmissible gastroenteritis virus spike protein expressed in plants. Vaccine, 2000,18:2023~2028 34  Lamphear B J, Streatfield S J, Jilka J M, et al. Delivery of subunit vaccines in maize seed. J. Controlled Release, 2002,85:169~180 35  Dalsgaard K, Uttenthal A, Jones T D, et al. Plant-derived vaccine protects target animals against a viral disease. Nat. Biotechnol.,1997,15: 248~252 36  Castanon S, Marin M S, Martin-Alonso J M, et al. Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus. J. Virol.,1999,73:4452~4455 37  Berinstein A, Vazquez-Rovere C, Asurmendi S, et al. Mucosal and systemic immunization elicited by Newcastle disease virus (NDV) transgenic plants as antigens. Vaccine, 2005,11:3450~3458 38 YuJ, Langridge W H R. A plant-based multicomponent vaccine protects mice from enteric diseas.  Nat.Biotechnol, 2001,19,548~552 39  Ma J K C. Genes, Greens and vaccines. Nat. Biotechnol.,2000,18:1141~1142 40  Daniell H, Lee S B, Panchal T, et al. Expression of the native cholero toxin choroplasts. J Mol Biol, 2001, 311(5):1001~1009 41  Tregoning J S, Nixon P, Kuroda H, et al. Exprenssion of tetanus toxin fragment C in tobaco chloroplasts,Nucleic Acids Res, 2003, 31(4):1174~1179 42  Lerouge P, et al. N-glycosylation of recombinant pharmaceutical glycoproteins produced in transgenic plants: towards a humanization of plant N-glycans. Curr. Pharmacol. Biotechnology,2000,1:347~354 43  Bakker H, et al. Galactose-extended glycans of antibodies produced by transgenic plants. Proc. Natl. Acad. Sci. U. S. A, 2001,98:2899~2904 44  王宝琴,张永光,王小龙.转基因植物疫苗与转基因植物抗体的研究近展.中国兽医科技,2003,33(9):29~33 45  朱国萍,徐冲. 植物生物反应器生产绿色疫苗研究进展. 生物工程进展,2002, 22(2):70~72 46  Rigano M, Walmsley A M. Expression systems and developments in plant-made vaccines. Immunology and Cell Biology, 2005,83(3):271~277
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