Abstract: Acorrding to the weakness of research on Complexation Extraction Process appling in separating Alkaloid , the author studied its application in extraction and separation of Matrine dilute solution compared with the traditional separation technology , based on analysing and discussing Complexation Extraction Process . The results showed that its thoery and practice was feasible that Complexation Extraction Process could extracte and separate Lewis Bases —Alkaloid existing in plants .