Abstract: G protein-coupled receptors (GPCRs) are a class of important cell surface receptors, which mediate many biological pathways through G proteins. Studies on signal transduction mechanisms mediated by GPCRs and using GPCRs as drug targets have become a new hot area for research. In this study, we analyzed the cAMP receptor-like GPCR genes of Magnaporthe grisea genome sequence through bioinformatics approaches. Our results will facilitate to further understanding the structures and functions of cAMP receptor-like GPCRs.