Abstract:

Transmissible gastroenteritis (TGE) is an acute highly contagious disease of pigs caused by transmissible gastroenteritis virus (TGEV). In this study, S gene sequences of several TGEV strains derived from different regions were analyzed for the homology and evolution. Sequence analysis of the S gene, including genetic distance measurement, phylogenetic tree analysis, and residue substitution analysis, showed that the S gene was highly conservative between each TGEV strains, but there existed the tendency of adenine nucleotide (A) mutation to thymidine nucleotide (T). This study shows that the nucleotide sequence analysis can form a base or further study on the virulence and epidemiological study of TGEV infections.