Abstract: The experiment was conducted to identify the best fertilizer ratio under the condition of located fertilizer of Wuchuan areas Inner, ‘Kexin1’ as experimental materials, random block design was adopted to study effects of M+NPK, M, NPK, NP, NK, PK, CK two years continuous positioning fertilization on yield and quality of potato. The results showed that, effects of fertilizers application on yield and rate of tuber are significant, yield increased range from 5.8% to 49.76%, rate of commercial potato increased range from 13.97% to 55.14%. M+NPK was the most significant, NPK was the second. Effects of fertilizers application on improve the content of N, P, K, amylase, amylopectin, reducing sugar, protein and amino acids, M+NPK was the most significant. The content of Zn was the highest in the treatment of M (16.00 mg/kg), the content of Ca, Se was the highest in the treatment of NK (208.40 mg/kg, 8.40 μg/kg), the content of Fe was the highest in the treatment of NP (206.03 mg/kg). The yield and quality of potato of M+NPK were higher, and it was the suitable match for local plant.