Abstract: As the fourth grain crop, it is important to improve the yield of potato and water and fertilizers resource use efficiency for meeting food demand and environmental sustainability. For exploring a way of efficient fertigation on potato, field plot trials were conducted to study the effects of different irrigation methods (drip irrigation, micro-irrigation and traditional irrigation) and different fertilizer rates (525, 600, 675, 750 kg/hm2) on potato yield and water use efficiency. The results showed that, drip irrigation significantly increase the seedling rate of potato from 85% of traditional irrigation treatment to 95%. Under the same amount of the fertilizer, drip irrigation increased potato yield and partial factor productivity of applied fertilizer. Compared to the traditional irrigation, drip irrigation saved 37% water and 55% fertilizer with the same yield. In conclusion, the drip irrigation is appropriate for increasing potato yield and improving the water use efficiency.