Abstract: Wheat plays an important role in food security, and foliar fertilizer and pesticide can promote wheat production. To analyze the effect of foliar fertilizer, pesticide and interaction on wheat yields, yields components and aphis control, the author conducted 12 treatments, comprised of two kinds of pesticides (imidacloprid and pvrethroids) and five foliar fertilizer (polypeptide, fulvic acid, monopotassium phosphate, Potassium nitrate, and zinc sulfate) in Huang- huai- hai plain. The results showed that under pesticide treatment without foliar fertilizer, wheat yield was only 7846.5 kg/hm², while combined with foliar fertilizer, such as polypeptide, fulvic acid, monopotassium phosphate, potassium nitrate, and zinc sulfate, the wheat yield increased significantly at a rate from 0.55% to 6.45%. Under the foliar treatment of polypeptide, fulvic acid, monopotassium phosphate, potassium nitrate, and zinc sulfate, the wheat yields increased by 1000.5, 265.5, 288.0, 96.0, and 43.5 kg/hm², respectively. Therefore, the interaction of foliar fertilizer and pesticide could promote wheat production, meanwhile had significant effect on aphis control with the rate of insect resistant more than 80%.