Abstract: In order to understand the risk of Mikania micrantha invasion in Dehong, the occurrence of Mikania micrantha was investigated and monitored in different habitats, and the system of risk analysis and assessment was established. Multi-index comprehensive scoring method was used to assess the invasion risk. The result showed that Mikania micrantha had regional distribution characteristics with three- dimensional distribution obviously and mainly distributed in low altitude tropic region, the occurrence area was nearly 31991.87 hm2, with invasion risk assessment value R of 68, Mikania micrantha had high ecological risk. At the moment, 304985.4 hm2 of potential occurrence area is still under threat of Mikania micrantha. Mikania micrantha mainly invades farmland, barren land and forest land, it not only causes great loss in agriculture, forestry and husbandry, but also threats eco-environment, we must take effective measures to prevent and control the status.