Abstract: The paper aims to ensure safe tobacco transplanting in tobacco growing areas of Hubei Province. A reckoning model for predicting the safe transplanting dates of tobacco seedlings in these areas was built by the multivariate regression analysis and the inverse distance weighting (IDW). Then, day sequences of the safe transplanting dates were obtained. Meanwhile, the altitude ranges for different transplanting periods in different transplanting regions were determined by the spatial-overlay technology. The results showed that: in four tobacco-growing areas of Enshi, Yichang, Shiyan and Xiangyang, seedlings should be transplanted: (1) around April 20 in the fields with a respective altitude below 715 km, 538 km, 507 km and 419 km; (2) from April 21 to 30 in the fields with a respective altitude of 715-1013 km, 538-833 km, 507-817 km and 419-720 km; (3) from May 1 to 10 in the fields with a respective altitude of 1013-1312 km, 833-1126 km, 817-1124 km and 720-1021 km; (4) from May 11 to 20 in the fields with a respective altitude of 1312-1606 km, 1126-1420 km, 1124-1432 km and 1021-1325 km; (5) around May 20 in the fields with a respective altitude above 1606 km, 1420 km, 1432 km and 1325 km. The safe transplanting dates obtained from this reckoning model were later than the present ones, which could reduce tobacco production risk caused by early-flowering induced by low temperature and maturity induced by high temperature.