Abstract: In order to solve the problem of fewer fruit setting number which was caused by abnormally fluctuated climate over the flowering stage of honey pear, the authors took 5 pear varieties from Shanghai Jinguan Honey Pear Plantations in 2015 as the materials, investigated the pear flowering stage and fruit setting number and comparatively analyzed the relationship between field investigation and the meteorological observation data in Fengxian area. The results showed that the suitable climate conditions for flowering and fruit setting were over 3-4 consecutive days of sunshine or sunny weather alternated with rain. The daily average temperature and the maximum temperature of the first 3 days in flowering stage or the peak period of flowering were no more than 15℃ and 25℃, respectively. In the ovary development period, it was easy to produce bad fruit when there was ice weather, and ice weather had greater influence on commercial fruit. The fruit setting number was cut down when high temperature occurred in pear blossom stage and shortened the flowering stage. Through cultivation measures like the pollen tree intercropping, grafting, artificial pollination, and the flowering stage regulated by microclimate effect etc, the influence of bad weather in blossom and fruit setting period could be avoided, and the commodity value and fruit setting number could be promoted.