Abstract: In order to reveal the water and fertilizer saving effect of drip irrigation cotton and provide technical parameters and theoretical basis, ‘Xinluzao No.42’ was used as experimental material, drip irrigation pot experiment was adopted, the response relationship between drip irrigation cotton ABA and field capacity of 10 cm soil layer was studied, the correlation and models were obtained under different nitrogen application levels during bud stage and boll stage. The results showed that ABA content was negatively correlated with field capacity of 10 cm soil layer under different treatments of pure nitrogen of 2, 4 and 6 g/pot during bud stage, the correlation coefficients (r) were -0.988, -0.894 and -0.980, respectively, their models were exponential function, logarithmic function and logarithmic function, respectively, the coefficients of fitting determination of the models (R²) were 0.954, 0.796 and 0.946, respectively. During boll stage, ABA content was negatively correlated with field capacity of 10 cm soil layer, and the correlation coefficients (r) were -0.781, -0.600 and 0.857, respectively, their models were quadratic function, quadratic function and logarithmic function, respectively, the coefficients of fitting determination of the models (R²) were 0.623, 0.911 and 0.965, respectively. Therefore, the fitting model functions properly described the response characteristics between drip irrigation cotton ABA and field capacity of 10 cm soil layer, and provided a new computing method and scientific basis for the estimation of water and fertilizer saving of drip irrigation cotton for oasis farming in inland arid region.