The Application of Model Organisms Drosophila melanogaster to the Toxicology of Water Environment Pollutants: Research Progress

doi:10.11924/j.issn.1000-6850.casb2020-0500

Abstract

Abstract:

The economic development and human activities have accelerated the destruction of the ecological environment, and the discharge of industrial and domestic sewage has aggravated the pollution of rivers and seawater, as well as the harmful substances to human health continuously. Drosophila melanogaster is a widely used model organism. Compared with other animal models, D. melanogaster has many advantages such as low feeding cost, short life cycle, high fecundity, relatively simple genetics, multiple mutant phenotypes and easy to be identified, which is a model organism widely used and suitable for studying human diseases and toxicology. In this review, the toxicological studies of volatile organic compounds, fluoroquinolones, heavy metals, pesticides and microbial toxins in the water environment on D. melanogaster were summarized, and the advantages of D. melanogaste as a classic model organism in studying toxicological mechanisms and screening anti-toxic drugs and the prospects for the future development trend of D. melanogaster were discussed.

Key words: model organisms, Drosophila melanogaster, toxicology model, water environment, pollution

CLC Number:

S948

Wu Jinlan, Lu Chenying, Wu Mingjiang, Tong Haibin. The Application of Model Organisms Drosophila melanogaster to the Toxicology of Water Environment Pollutants: Research Progress[J]. Chinese Agricultural Science Bulletin, 2021, 37(17): 87-93.

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