Abstract:

In order to obtain a more suitable preparation process of apigenin with hydroxypropyl-β-cyclodextrin, technology of inclusion was researched. The inclusion rate was an index, the effects of reaction process was inquired by reactant ratio, ethanol concentration, reaction time and temperature. Then, the most suitable technology of inclusion compound of apigenin with hydroxypropyl-β-cyclodextrin was optimized by orthogonal design. The best technology of inclusion compound of apigenin with hydroxypropyl-β-cyclodextrin as follows: reactant ratio of apigenin and hydroxypropyl-β-cyclodextrin was 1:3, ethanol concentration was 50%, reaction time, temperature was 1 h at 50℃. The optimum result was achieved at this condition and the inclusion rate of 42.8% was gained. Through exploring to different inclusion methods and different inclusion conditions, a suitable inclusion compound of apigenin with hydroxypropyl-β-cyclodextrin preparation process was obtained, and some theoretical basis was provided to the application development of apigenin.