Abstract: To investigate the expression of EGXA (the multi-functional enzyme with the activities of exo-β-1,4-glucanase, endo-β-1,4-glucanase and endo-β-1,4-xylanase) gene in different digestive organs of Pomacea canaliculata, the expression amount of the EGXA gene in the snail's stomach, intestine, hepatopancreas was evaluated by real-time fluorescent quantitative PCR technique. The results showed that the expression levels (2-⊿⊿Ct) of EGXA gene in the snail's stomach, intestine, hepatopancreas were 1.56±0.13, 0.08±0.01, 0.12±0.03 respectively. It suggested that the EGXA was secreted by the stomach of Pomacea canaliculata chiefly.