Abstract: For studying the effects of different energy rations on blood physiological and biochemical indexes of Lanzhou Fat-Tailed Sheep, Small-Tailed Han sheep, Tibetan sheep and high hybrid German Merino. 120 sheep (Lanzhou Fat-Tailed sheep (n=30), Small-Tailed Han sheep (n=30), Tibet sheep (n=30) and high hybrid German Merino (n=30)) within well-developed, same age and weight were selected in the study, respectively. Every group was divided equally into three subgroups randomly and each subgroup had 10. The contents of blood glucose(GLU), total protein(TP), albumin(ALB), globulin(GLO), triglyceride(TG), total cholesterol(CHO), high-density lipoprotein(HDL) and low-density lipoprotein(LDL) were determined by Automatic Chemistry Analyzer. The results showed that: With the increasing levels of dietary energy, the contents of TP, ALB, GLO were reduced in the same groups. however, the percent of TG and total CHO of blood under high energy ration was significantly higher than intermediate and low energy ration (P<0.05), at the same energy ration, the GLU percent in the blood of Small-Tailed Han sheep and Tibetan sheep was significantly (P<0.05) or very significantly (P<0.01) lower than Lanzhou Fat-Tailed sheep and high hybrid German Merino. The contents of total (TP), (ALB) and (GLO) in the blood of Lanzhou Fat-Tailed sheep and Small-Tailed Han sheep was significantly (P<0.05) or very significantly (P<0.01) higher than Tibetan Sheep and high hybrid Germany Merino.