Abstract: In order to understand the control effect of agricultural non-point source pollution by the artificial ponds- wetlands combined system at small watershed within specific natural conditions in north Zhejiang Province, the author studied the control effect of agricultural non-point source pollution of total nitrogen (TN) and total phosphorus (TP) and other pollutants by artificial ponds-wetlands coupled systems in Shenxi River watershed in Anji County through continuous sampling and monitoring. The results showed that: from May to October in 2012, the Zhongzhang River artificial pond water TN concentration was 3.7- 6.4 mg/L, the TN removal rate was 9.9%- 63.4% , and its removal efficiency of TN was strongly influenced by water TN concentration; the Zhongzhang River artificial channels water TN concentrations between 2.5-5.1 mg/L, the TN removal rate was 5.0%-48.1%; the TP removal rate were mainly over 30% in the artificial pond at Hong Village and Shenxi Village, and when the TP concentration of artificial pond water was higher, it also had a better removal effect; the purification effect of TN and TP was better at Hong Village, Shenxi River downstream wetlands, the TN removal rate was 25.0%-96.0%, and removal rate of TP was 21.8%-98.1%. The combined system of artificial ponds- wetlands annual average TN removal rate was 60.4% , the highest rate reached 86.8%, the average TP removal rate was 78.6%, the highest rate reached 94.9%, and Shenxi River watershed non-point source pollution management achieved good effect by the artificial wetlands combined system.