Abstract: In order to study the effect of domestic waste compost on the growth of Celosia cristata and soil property, a pot experiment was developed with Celosia cristata grown in substrates at different proportions of soil and domestic waste compost. The property of the mixed substrates and the growth index of Celosia cristata were measured. The results showed that the contents of organic matter, nitrogen and available phosphorus were significantly raised by adding domestic waste compost. When the compost content was from 5% to 100%, the content of organic matter was raised from 22.68 g/kg to 317.71 g/kg, nitrogen was from 1.36 g/kg to 14.9 g/kg and available phosphorus was from 33.18 mg/kg to 228.25 mg/kg. The detected 8 heavy metal contents in domestic waste compost were all less than the level of organic media standards for green use, among which only the content of Cu was raised by adding the compost, but there was no significant differences between the control soil and mixed substrates of compost content of 5%-80%. The shoot and roots biomass of Celosia cristata which grew in the substrates of 5%-20% domestic waste compost were significantly higher than that of the control; the plants grew in substrates of 10% domestic waste compost were the best，the root biomass was 3.61 times of the control. Then, it is concluded that the domestic waste compost can significantly improve growth status and quality of Celosia cristata, and be used as substrate for flower cultivation, and 5%-20% compost in soil could be acceptable.