Abstract: The forecast and management system for main wheat disease was set up by means of Visual Basic 6.0 and multi-media technology. The system was made up of diagnosing module, forecast and control decision module, system explanation module. The system was driven with menu to select and person-computer interlocutory way. Running the system in properly condition, choosing the needed item or inputting necessary information, the users could achieve satisfactory running effect. The system of person-computer alternation interface was friendly, and all operation had screen Chinese characters hint. After being tested, the system achieved our designing aim, it can run exactly and unfailingly. It had evident superiority, contrasted with traditional management system.