Abstract: In order to understand the effects of soil properties on degradation characteristics and bioavailability of veterinary antibiotics in soils, 10 kinds of typical vegetable soils with different physical and chemical properties were selected for the experiment. After adding 4 kinds of antibiotics (oxytetracycline, enrofloxacin, sulfamethazine and tylosin) at different concentrations (1, 5, 20 mg/kg) and adjusting moisture content of water holding capacity to 65%, soils treated with antibiotics were incubated at 25℃. Dynamic changes of residue and bioavailability of 4 kinds of antibiotics in soils were monitored. The results showed that the degradation rates of antibiotics in soils were significantly higher at the early stage of the experiment (＜20 days) than those of the later (50-100 days). Accumulated degradation amount of antibiotics in soils increased with the increasing concentration of antibiotics. But the degradation proportion decreased with the increasing amount of antibiotics. The degradation rate of 4 kinds of antibiotics in soils decreased in the order of sulfamethazine＞ enrofloxacin＞oxytetracycline＞tylosin. Decline of available antibiotics in soils was more obvious than residue of the corresponding antibiotics in the earlier stage. The degradation rates of all antibiotics were mainly and negatively correlated with the contents of clay and iron oxides, and slightly and positively correlated with the content of organic matter. No correlation was found between the degradation rate of antibiotics and pH, CEC. At the beginning of incubation (5 days), content of available antibiotics was negatively correlated with the contents of clay and iron oxides, and positively correlated with the content of organic matter. However, these correlations decreased with the incubation time.