Abstract: To select suitable kinds and dosages of herbicides and popularize simple and efficient cultivation techniques of millet in spring-seeding and early-maturing region, four main herbicides in local agricultural material market and two spraying methods were used study the herbicides’ effect on plant control effectiveness, fresh weight control effectiveness, yield, emergence rate and plant height. The results showed that: (1) the control effectiveness of 10% monosulfuron to cotyledon weeds was more than 92%, and the effect was consistent among five concentrations; the control effectiveness of 25 and 40 days to monocotyledon and cotyledon weeds followed an order of: atrazine sprayed after the sowing and before seedling≥ 10% monosulfuron≥ MCPA-Na≥ atrazine sprayed after seedling≥ 2,4-D butyl ester, the best control effectiveness was found in atrazine sprayed after the sowing and before seedling, and the optimum dosages were 3000 and 4500 g/hm²; (2) 3000 and 2250 g/hm² treatments of 10% monosulfuron and 750 and 1500 g/hm² treatment of atrazine sprayed after the sowing and before seedling increased the yield significantly; (3) 750 and 1500 g/hm² treatment of atrazine sprayed after sowing and before seedling, 1500 and 2250 g/hm² treatment of 10% monosulfuron and 1500 g/hm² treatment of 2,4-D butyl ester had little influence on sprouting; 10% monosulfuron and atrazine sprayed after sowing and before seedling inhibited growth strongly in the early stage. In conclusion, the suitable herbicides for the region were 10% monosulfuron with the dosage of 1500 and 2250 g/hm² and atrazine sprayed after sowing and before seedling with the dosage of 1500 g/hm².