Abstract: To screen out economic, efficient and safe chemical weed control method to control oilseed rape field weeds effectively, and improve yield and benefit of oilseed rape, the authors studied the safety and effects of 2 chemical herbicides at oilseed rape seedling stage with different concentrations. At the same time, the input and output of different weed control methods were analyzed with the CK of artificial weeding and non-weeding. The results showed that the yield of oilseed rape was significantly different between different weed control methods; the chemical weed control method had good control effect on oilseed rape field weeds, it could significantly reduce the input of labor and production cost, and improve the economic benefit. Different chemical weed control methods all showed good weed control effect after 35 days of application; the weed control effect was the best with timely spraying 900 mL 21.2% sinensis·amine·benazolin suspending agent added 900 kg water per hectare at 4—5 leaf stage of oilseed rape and 3—4 leaf stage of weeds, it was safe to oilseed rape growth and could be used as a chemical weed control method in winter oilseed rape field at seedling stage in the production.