Abstract: To observe the effect on SOD and GSH-PX activities, MDA content in serum, the survival time under hypoxic condition and swimming time of mice with senile model caused by D-galatose and meanwhile administered with polysaccharide from Portulaca oleracea L.(POP)of 100, 200, 400 mg/ orally, the results showed that SOD and GSH-PX activities in serum differently rose, MDA content significantly dropped. Meanwhile, the survival time under hypoxic condition and swimming time were significantly prolonged. It was found that POP had the obvious effect on anti-senility.