Abstract: Single factor randomized block design, with the measurement height, branches and fresh weight, was employed to analysis the effects of 5 fertilizers on the growth and yield of Houttuynia cordata Thunb. The result showed that the plant grew slowly at the early stage after transplanted, the application of organic fertilizers was beneficial to the development of plant height and branches at later stage, and manure of duck acted as the best one. It also showed that the application of organic fertilizers increased the yield of Houttuynia cordata Thunb, with a highest yield was detected in application of duck excretion at moderate level, especially for the underground part of the plant, which was higher than the application of chemical and traditional fertilizer. From the result of the test, we suggested that duck excrement was the best one of organic fertilizer for the cultivation of Houttuynia cordata Thunb, and can be mixed with other organic fertilizers, such as manure of human and pig, incooperation with and grow moreover a small amount of quick-acting chemical fertilizer is needed at earlier and later growth stage of the plant. In the application of organic fertilizers, 108000 kg/hm2 of human manure, 54000 kg/hm2of pig manure and 45000 kg/hm2 of duck manure were recommended respectively.