Abstract: Conjugated linoleic acid (CLA) is polyunsaturated fatty acid (PUFA), which is a collective term for a group of geometric and positional isomers of linoleic acid. CLA has a wide range of healthpromotion potential, including antitumor, antiatherogenic, antidiabetogenic, a reduction in body fat mass, and an increase in immune modulating properties and in growth. This paper gives a review on the role of conjugated linoleic acid on pigs immunomodulatory mechanism. It provides a academic foundation for further exploitation and utilization of CLA.