Progress in Studys of Ginkgolides Contents Regulating

Abstract

Abstract: Ginkgolides and bilobalides are believed to be responsible for most of the pharmacological properties of Ginkgo biloba extract. Several factors and various regulating methods of the accumulation of ginkgolides and bilobalides were summarized. The research show that chlorocholine chloride and ethylene were sprayed can reduced the synthesition of endogenesis hormone by feedback to increase the accumulation of pre-ginkgolides. Gibberellin have a inhibition mechanism same with chlorocholine chloride and ethylene, and regulating to the accumulation of the RNA of gibbere20- oxidase and gibberellin3β-hydroxylase by feedback inhibit. Furthermore, other regulating methods such as 2,3-epoxysqualene cyclase was inhibited by 2,3-epoxysqualene in order to hold up sterol synthesize pathway so that the IPP of MVA pathway can take party in lactone sythesize were introduced in this report.

CLC Number:

Q945

Zhu Jun, Xu Feng, Liao Yongling, Wang Yan, Cheng ShuiYuan,. Progress in Studys of Ginkgolides Contents Regulating[J]. Chinese Agricultural Science Bulletin, 2007, 23(7): 301-301.

References

[1] Braquet, P. The ginkgolides:potent platelet-activating factor antagonists isolated from Ginkgo biloba leaves:chemistry,pharmacology and clinical applications.Drugs of the Future,1987,12:643-649.
[2] Drieu, K., Jaggy, H. History,development and constituents of EGb 761.In:van Beek,T.A.(Ed.),Ginkgo Biloba. Harwood Academic Publishers,Amsterdam,2000,12:267-277.
[3] Paul F. Smith, Karyn Maclennan, Cynthia L. Darlington.The neuroprotective properties of the Ginkgo biloba leaves review of the possible relationship to platelet-activating factor(PAF).Journal of Ethnopharmacology,1996,50:131-139.
[4] Little, H. N. and Bloch, K. Studies on the utilization of acetic acid for the biological synthesis of cholesterol. J. Biol. Chem. 1950,138,33-46.
[5] Lynen, F., Reichart, E. and Rueff, L. Zum biologischen Abbau der Essigs?ure VI, “aktivierte Essigs?ure”, ihre Isolierung aus Hefe und ih re chemische Natur. Liebigs Ann. Chem, 1951,574:1-32.
[6] Wolf D. E., Hoffmann C.H., Aldrich P.E., et al. ?-hydroxy-?-methyl-d-dihydroxy-?methylvalericacid (divalonic acid), a new biological factor. J. Am. Chem. Soc, 1956,78:4499.
[7] Rohmer M., Knani M., Simonin P., et al. Isoprenoid biosynthesis in bact eria: a novel pathway for early steps leading to isopentenyl diphosphate. Biochem. J, 1993,295,517-524.
[8] Schwender J., Lichtenthaler H.K., Seemann M.,et al. Biosynthesis of isoprenoid chains of chlorophylls and plastoquinone in Scenedesmus by a novel pathway. in P. Mathis (ed.), Photosynthesis: from Light to Biosp here. Kluwer Academic Publishers, Amsterdam, 1995:1001-1004.
[9] Schwender J., Seemann M., Lichtenthaler H.K.,et al. Biosynthesis of isoprenoids (carotenoids, sterols, prenyl sidechains of chlorophyll and plastoquinone) via a novel pyruvate/glycero-aldehyde-3-phosphate non-mevalonate pathway in the green alga Scenedesmus. Biochem, 1996,316:73-80.
[10] Nakanishi K. Structure of bilobalide a rare tert - buty1 containing sesquiterpenoid related to the C20 -ginkgolides . J Am Chem soc, 1971,93(14):3544.
[11] Neau E , Cartayrade A , Balz J P , et al . Ginkgolide andbilobalide biosynthesis in Ginkgo biloba. Ⅱ: Identification of a possible intermediate compound by using inhibitors of cytochrome P - 450 - dependent oxygenases[J ] . Plant Physiol Biochem, 1997,35(11):869.
[12] Lichtenthaler H.K., Schwender J., Seemann M.. Carotenoid biosynthesis in green algae proceeds via a novel biosynthetic pathway. in P. Mathis (ed.), Photosynthesis: from Light to Biosphere. Kluwer Academic Publishers, Amsterdam, 1995:115-118.
[13] Croteau R , Burbott AJ , Loomis WD. Apparent energy deficiency in mono- and sequi-terpene biosynthesis in peppermint [J]. Phytochemistry, 1972,11:2937-2948.
[14] 冷平生.光强与光质对银杏光合作用及黄酮苷与萜类内酯含量的影响.植物资源与环境学报,2002,11(1):1-4.
[15] Dogbo O , Laferriere A , d’Harlingue A, et al. Carotenoid biosynthesis: Isolation and characterization of a bifunctional enzyme catalyzing the synthesis of phytoene. Proc Natl Acad Sci USA, 1988,85:7054-7058.
[16] Giuliano G, Bartley GE , Scolnik PA. Regulation of carotenoid biosynthesis during tomato development . Plant Cell, 1993,5:379-387.
[17] Ait- AliT, Frances S, Weller J,Letal.Regulation of gibbere20- oxidase and gibberellin3β-hydroxylase transcript accumulation during de-etiolation of pea seedling.PlantPhysiol,1999,12:783-791.
[18] Cowling R J, Kamiya Y, Seto, Hetal. Gibberellindose respon regulation of GA4 gene transcript levels in Arabidopsis.Plant Physiol,1998,117:1195-1203.
[19] XuY L,Li L,Gage D,Aetal.Feed back regulation of GA5 expression and metabolic engineering of gibberell in levels in Arbidopsis.The Plant Cell,1999,11:927-935.
[20] 郭志刚,冯莹,刘瑞芝.生长调节物质对紫杉醇和紫杉类化合物合成的调节作用.天然产物开发与研究,2002,12(3):22-26.
[21] 冷平生,苏淑钗.银杏萜内酯的分布与矮壮素对其生物合成的调节.植物资源与环境学报,2004,13(2):54-55.
[22] 段翠芳,曾日中,黎瑜.激素对巴西橡胶树橡胶生物合成的调控.热带农业科学,2004,24(5):61-68.
[23] 谢宝东,王华田,吴国意.乙烯利对银杏叶黄酮和内酯含量的影响.山东林业科技,2002,140(3):1-3.
[24] Zeevaart JAD , Creelman RA1.Metabolism and physiology of abscisic acid。 Annu Rev Plant Physiol Mol Boil , 1988,39:439-441.
[25] Parry AD. Abscisic acid metabolism1 Methods in Plant Biochem, 1993,9:381-402.
[26] 杨洪强,接玉玲.高等植物脱落酸的生物合成及其调控.植物生理学通讯,2001,37(5):457-462.
[27] Sagi M, Fluhr R , Lips SH1 Aldehyde oxidase and xanthine dehydrogenase in a flacca tomato mutant with deficient abscisic acid and wilty phenotype1 Plant Physio , 1999,120(2):571-577.
[28] 张鹤鸣.银杏萜内酯的化学性质及合成.广州中医药大学学报,2000,17(3):266-270.
[29] 戴均贵,朱蔚华,吴蕴祺,等.前体及真菌诱导子对银杏悬浮培养细胞产生银杏内酯B的影响.药学学报,2000,35(2):151-155.