Abstract: The paper summarized the practices of health assessment of ecosystem both at home and abroad, and established an index system of ecosystem health assessment of the lakeside zone of Wuli lake by taking the theory of ecosystem health and “pressure-state-response” model as a basis. The results evaluated comprehensively by the method of stratification analysis showed that the scores of health status of the lakeside zone of Wuli lake was 73.05, which meant the ecosystem was healthy. The pressure mainly came from human activity. The vigor and entertainment function of ecosystem were quite good, but the quality of water, air and soil should be improved. The protection of biodiversity should be enhanced too.