Abstract: To probe into the effect of fermented pu’er tea in reducing blood lipids and its physiologically active part. The model of metabolic disturbance of lipid—preventive tested sample was adopted. Using systematic solvents (chloroform, ethyl acetate, butanol) extract the fermented pu’er tea. Observe the effects of different extracts on reducing the serum levels of TC, TG, HDL-C, LDL-C, which were established through high-fat-diet. The results showed that fermented pu’er tea can obviously reduce blood lipid and ethyl acetate extracts was the active part.