Abstract: In order to study the effect of different storage methods on post-harvest physiology and storage quality of Sinkiang thick-skinned melon . Sinkiang thick-skinned melon was preserved in the experiment with three storage methods: cold storage; cold storage with intermittent ozone treatment; controlled atmosphere storage (CA) with 4%~6% O2 and 0.2% ~ 0.5% CO2. The results showed that CA storage restrained respiration rate of melon markedly, postponed senescence process and it also controlled the decline of flesh firmness and content of titratable acidity, total soluble solids, vitamin C and deoxidized sugar effectively. CA storage reduced rotten exponent of melon, kept better quality and flavor. The test also found that the effect of cold storage with intermittent ozone treatment was better than cold storage, and CA storage had remarkable effect compared with cold storage with intermittent ozone treatment.