Abstract: With the fast development of biopharmacy,transgenic chicken oviduct bioreactor is going to be the focus of people’s attention.For its excellent advantages,transgenic chicken will be one of rising industries in the field of biopharmacy and hot spot of science study.Now,the most successful method for producing transgenic chicken is mediated by retrovirus transferring gene into it, and transgenic chicken have been produced by this method.The review mainly summarizes the advantages of producing transgenic chicken with chicken,and the development course of transgenic chicken, and the method and process of producing transgenic chicken with retrovirus,and the study progress of transgenic chicken.The significance and existent problems of transgenic chicken are also discussed.