Abstract: Objective:To optimize the preparation process of the Shuanghuanglian oral liquid. Methods:An orthogonal design was adopted and optimized the process of preparation process in shuanghuanglian oral liquid.We determined the index of orthogonal experiment in apparent grade to study the influence made by different preparation processes of Shuanghuanglian Oral liquid upon the colour and the clarity. Results: The optimum conditions for shuanghuanglian oral liquid by orthogonal test optimized process were as follows:water for ten times the quantity of medicinal materials in the process of decoction, ethanol with 75% in the process of deposition,pH with 7.0,12 hours about laying aside time. Conclusion:The result of this experiment is reliable. Clarity of the oral solution prepared by the optimized process is better. Manufacturing process consumes shorter time, so it is propitious to the batch production.