Abstract:

Histones, as basic components of nucleosome , are essential to chromatin structure and function. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, these variants change the conformation and stability of nucleosome to facilitate transcriptional activation or deactivation, DNA repairing, and others. The histone chaperones are needed during DNA replication progess for disassembly and rebuilding the chromatin structure. the histone chaperones are very important to the chromation structure stability and gene expression.