Abstract:

Mouse and human NYGGF4 is a novel gene, which involves in regulation of adipose precursor cells proliferation and may be related to occurrence and development of obesity. In this study, full-length coding sequence of chicken NYGGF4 homologous gene was gained for the first time. Genetic homology and protein functions of chicken NYGGF4 homologous gene were predicted using bioinformatics methods, and tissue expression pattern was also analyzed using Semi-quantitative RT-PCR technology. The results show that chicken NYGGF4 homologous gene full-length coding sequence is 654nt, and evolution is conservative. In chicken, the gene expresses in a variety of organizations and possesses a phosphotyrosine interacting domain(PID).Encoding PID proteins widely involve in physiological processes, such as neural development, immune, organizational balance and cell growth, which indicates chicken NYGGF4 homologous gene is a novel gene that maybe possesses multiple functions.