Abstract:

Mitochondrion has close relationship with apoptosis. Some active substances, such as Cytochrome C, A IF, Smac /D IABLO are released from mitochondrion, intermembrane space and the MPTP channel of mitochondrion is opened. And promote the generation of reactive oxygen species.Then the electrochemical proton gradient between the outside and the inside membrane of mitochondrion is weakened,which results in decline of the synthesis of ATP and active substances mentioned above active caspase. So apoptosis is induced.