藻胆蛋白源生物活性肽研究进展

doi:10.11924/j.issn.1000-6850.casb2021-0005

摘要/Abstract

摘要：

本研究旨在为藻胆蛋白源生物活性肽的发掘、构-效关系表征提供重要参考,推动藻胆蛋白源生物活性肽的研发和应用。本研究综述了具有不同生物学活性的藻胆蛋白源活性肽,包括抗氧化肽、降血压肽、免疫调节肽、降糖肽、抗菌肽和抗炎肽等,归纳了藻胆蛋白源生物活性肽的来源、制备、结构鉴定、功能表征及构-效关系研究进展,指出利用传统方法研发生物活性肽存在一定盲目性,提出利用生物信息学与传统方法相结合有利于高效发掘新型藻胆蛋白源生物活性肽,为生物活性肽的研发提供了新策略。

关键词: 藻胆蛋白, 生物活性肽, 制备, 功能, 结构, 构-效关系

Abstract:

The purpose of this study is to provide references for discovery and structure-activity relationship characterization of phycobiliprotein-derived bioactive peptides, and promote the development and application of phycobiliprotein-derived bioactive peptides. In this paper, phycobiliprotein-derived bioactive peptides with different biological activities, including antioxidant peptides, antihypertensive peptides, immunomodulatory peptides, hypoglycemic peptides, antibacterial peptides and anti-inflammatory peptides, were reviewed. The sources, preparation, structure, function, and structure-activity relationship of phycobiliprotein-derived bioactive peptides were summarized. Finally, it was pointed out that there was certain blindness in the research and development of bioactive peptides using traditional methods, however, the combination of bioinformatics and traditional methods was conducive to efficient exploring of novel bioactive peptides, and the study could provide a new approach for the development of phycobiliprotein-derived bioactive peptides.

Key words: phycobiliprotein, bioactive peptide, preparation, function, structure, structure-activity relationship

中图分类号:

S188

李富强, 张廷新, 李晓杰, 朱丽萍, 颜世敢. 藻胆蛋白源生物活性肽研究进展[J]. 中国农学通报, 2021, 37(27): 70-76.

Li Fuqiang, Zhang Tingxin, Li Xiaojie, Zhu Liping, Yan Shigan. Bioactive Peptides Derived from Phycobiliprotein: A Review[J]. Chinese Agricultural Science Bulletin, 2021, 37(27): 70-76.

图/表 1

参考文献 62

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活性肽的名称	活性肽的结构	活性肽的藻来源	文献
抗氧化肽	RYVSYALLAGDPSVLEDRC	条斑紫菜	[23]
抗氧化肽	PNN	螺旋藻	[24]
抗氧化肽	DYYKR	紫菜	[38]
抗炎肽	LRDGEIILRY	掌状红皮藻	[27]
降血压肽	AILAGDPSVLEDR	红藻	[31]
降血压肽	VVGGTGPVDEWGIAGAR	红藻	[31]
降血压肽	YRD	日本掌状红皮藻	[32,33]
降血压肽	LDY	日本掌状红皮藻	[32,33]
降血压肽	LRY	日本掌状红皮藻	[32,33]
降血压肽	LF	日本条斑紫菜	[32,34]
降血压肽	VY	日本裙带菜	[32,35]
降血压肽	FY	日本裙带菜	[32,35]
降血压肽	TYIA	紫菜	[38]
降血糖肽	YLVA	紫菜	[38]
抗肿瘤肽	VPGTPKNLDSPR	坛紫菜	[48]
抗肿瘤肽	MPAPSCALPRSVVPPR	坛紫菜	[48]
抗肿瘤肽	QTDDNHSNVLWAGFSR	坛紫菜	[49]
抗肿瘤肽	QTDDNHSNVLWAGFSR	坛紫菜	[49]
抗菌肽	KLVDASHIRLATGDVAVRA	螺旋藻	[53]
抗菌肽	ATHDNCCLRQS	螺旋藻渣	[54,55]

活性肽的名称	活性肽的结构	活性肽的藻来源	文献
抗氧化肽	RYVSYALLAGDPSVLEDRC	条斑紫菜	[23]
抗氧化肽	PNN	螺旋藻	[24]
抗氧化肽	DYYKR	紫菜	[38]
抗炎肽	LRDGEIILRY	掌状红皮藻	[27]
降血压肽	AILAGDPSVLEDR	红藻	[31]
降血压肽	VVGGTGPVDEWGIAGAR	红藻	[31]
降血压肽	YRD	日本掌状红皮藻	[32,33]
降血压肽	LDY	日本掌状红皮藻	[32,33]
降血压肽	LRY	日本掌状红皮藻	[32,33]
降血压肽	LF	日本条斑紫菜	[32,34]
降血压肽	VY	日本裙带菜	[32,35]
降血压肽	FY	日本裙带菜	[32,35]
降血压肽	TYIA	紫菜	[38]
降血糖肽	YLVA	紫菜	[38]
抗肿瘤肽	VPGTPKNLDSPR	坛紫菜	[48]
抗肿瘤肽	MPAPSCALPRSVVPPR	坛紫菜	[48]
抗肿瘤肽	QTDDNHSNVLWAGFSR	坛紫菜	[49]
抗肿瘤肽	QTDDNHSNVLWAGFSR	坛紫菜	[49]
抗菌肽	KLVDASHIRLATGDVAVRA	螺旋藻	[53]
抗菌肽	ATHDNCCLRQS	螺旋藻渣	[54,55]