膜联蛋白在人兽共患蠕虫病感染中作用机制的研究进展

doi:10.11924/j.issn.1000-6850.casb2025-0017

中国农学通报 ›› 2025, Vol. 41 ›› Issue (23): 125-132.doi: 10.11924/j.issn.1000-6850.casb2025-0017

• 畜牧·动物医学·蚕·蜂 • 上一篇

膜联蛋白在人兽共患蠕虫病感染中作用机制的研究进展

何沛霞¹(), 王卓², 王梦奇², 段蕊², 赵昱源², 王思睿², 孙树民¹^,²()

¹ 云南农业大学动物医学院，昆明 650000
² 内蒙古民族大学动物科技学院，内蒙古通辽 028000

收稿日期:2025-01-02 修回日期:2025-05-08 出版日期:2025-08-19 发布日期:2025-08-19
通讯作者:
孙树民，男，1973年出生，教授，博士，硕士生导师，研究方向：人兽共患寄生虫病。通信地址：650000 云南省昆明市盘龙区沣源路452号云南农业大学，E-mail：shums1975@163.com。
作者简介:
何沛霞，女，2000年出生，广西玉林人，学士，研究方向：人兽共患寄生虫病。通信地址：650000 云南省昆明市盘龙区沣源路452号云南农业大学，E-mail：18277567268@163.com。
基金资助:
国家自然科学基金“猪囊尾蚴膜联蛋白介导免疫抑制的分子机制研究”(32160842); 国家自然科学基金“猪囊尾蚴丝氨酸蛋白酶抑制剂介导免疫逃避的分子机制研究”(31960707); 国家自然科学基金“亚洲带绦虫囊尾蚴侵袭宿主肝脏的分子机制研究”(32460893); 内蒙古自治区科技计划项目“犊牛免疫增强剂-饲药用真菌液体发酵物功能研发”(2022YFDZ0049); 云南省重大科技专项“云南省牛羊主要疾病防控关键技术及产品研发”(202402AE090074); 建设面向南亚东南亚科技创新中心专项“云南省兽医公共卫生国际联合研发中心”(202403AP140033)

Research Progress on Mechanism of Annexin in Zoonotic Helminth Diseases

HE Peixia¹(), WANG Zhuo², WANG Mengqi², DUAN Rui², ZHAO Yuyuan², WANG Sirui², SUN Shumin¹^,²()

¹ College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650000
² IMUN College of animal science and technology, Inner Mongolia Minzu University, Tongliao, Inner Mongolia 028000

Received:2025-01-02 Revised:2025-05-08 Published:2025-08-19 Online:2025-08-19

摘要/Abstract

摘要：

膜联蛋白(Anx)为一类钙依赖性磷脂结合蛋白，具有独特的结构域，在细胞生命活动中发挥调节作用，并与多种疾病相关。本研究主要综述了Anx的结构与分类，重点关注其在广州管圆线虫、猪囊尾蚴、细粒棘球蚴、多头绦虫和血吸虫等重要人兽共患蠕虫病感染中的免疫应答机制研究进展。这些研究揭示了蠕虫Anx通过抗凝血、调节免疫细胞凋亡、干扰宿主凝血系统等多种机制，参与免疫逃避，促进蠕虫在宿主体内的生存。深入理解Anx在人兽共患蠕虫病中的作用机制，为开发新型诊断靶标、治疗策略和疫苗设计提供理论基础，具有重要的生物学意义和应用价值。

关键词: 膜联蛋白, 人兽共患蠕虫病, 免疫应答, 作用机制, 疫苗靶点, 药物靶点

Abstract:

Annexins (Anx) are a class of calcium-dependent phospholipid-binding proteins with unique domains, which play regulatory roles in cellular life activities and are associated with various diseases. This study mainly reviews the structure and classification of Anx, with a focus on the research progress of its immune response mechanisms in important zoonotic helminth infections such as Angiostrongylus cantonensis, Taenia solium, Echinococcus granulosus, Taenia multiceps, and Schistosoma. These studies revealed that Anx participated in immune evasion and promoted the survival of worms in the host through various mechanisms such as anticoagulation, regulation of immune cell apoptosis, and interference with the host coagulation system. It is of great biological significance and application value to deeply understand the mechanism of Anx in zoonotic helminthiasis and provide a theoretical basis for the development of new diagnostic targets, treatment strategies and vaccine design.

Key words: annexin, zoonotic helminth diseases, immune response, mechanism of action, vaccine targets, drug targets

何沛霞, 王卓, 王梦奇, 段蕊, 赵昱源, 王思睿, 孙树民. 膜联蛋白在人兽共患蠕虫病感染中作用机制的研究进展[J]. 中国农学通报, 2025, 41(23): 125-132.

HE Peixia, WANG Zhuo, WANG Mengqi, DUAN Rui, ZHAO Yuyuan, WANG Sirui, SUN Shumin. Research Progress on Mechanism of Annexin in Zoonotic Helminth Diseases[J]. Chinese Agricultural Science Bulletin, 2025, 41(23): 125-132.

图/表 2

参考文献 26

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寄生虫种类	Anx种类	功能
广州管圆线虫^[19]	Anx A2	Anx A2通过结合AcGal-1和激活凋亡信号通路下游的JNK途径来诱导巨噬细胞凋亡，帮助虫体达到免疫逃避。
猪囊尾蚴^[20]	Anx B1、Anx B2、Anx B3	抗凝血、形成稳定可逆的细胞骨架，构建幼虫发育环境，抑制宿主免疫反应。
细粒棘球蚴^[21]	EgAnx B3	EgAnx B3在PSC入侵最终宿主的过程中起关键作用。
细粒棘球蚴^[21]	EgAnx B38	EgAnx B38参与了PSCs与最终宿主之间的相互作用。其具体功能有待进一步研究。
多头绦虫^[22]	TmAnx B2	TmAnx B2可能在多头绦虫的发育和入侵中间宿主中起重要作用。
多头绦虫^[22]	TmAnx B3	TmAnx B3与宿主-寄生虫的营养和相互作用有关，在成虫发育过程中起关键作用。
血吸虫^[23-24]	Anx B30、Anx B22、SjAnx A13	具有纤溶和抗凝血活性；影响发育和繁殖，并通过外分泌体参与宿主-寄生虫相互作用。

寄生虫种类	Anx种类	功能
广州管圆线虫^[19]	Anx A2	Anx A2通过结合AcGal-1和激活凋亡信号通路下游的JNK途径来诱导巨噬细胞凋亡，帮助虫体达到免疫逃避。
猪囊尾蚴^[20]	Anx B1、Anx B2、Anx B3	抗凝血、形成稳定可逆的细胞骨架，构建幼虫发育环境，抑制宿主免疫反应。
细粒棘球蚴^[21]	EgAnx B3	EgAnx B3在PSC入侵最终宿主的过程中起关键作用。
细粒棘球蚴^[21]	EgAnx B38	EgAnx B38参与了PSCs与最终宿主之间的相互作用。其具体功能有待进一步研究。
多头绦虫^[22]	TmAnx B2	TmAnx B2可能在多头绦虫的发育和入侵中间宿主中起重要作用。
多头绦虫^[22]	TmAnx B3	TmAnx B3与宿主-寄生虫的营养和相互作用有关，在成虫发育过程中起关键作用。
血吸虫^[23-24]	Anx B30、Anx B22、SjAnx A13	具有纤溶和抗凝血活性；影响发育和繁殖，并通过外分泌体参与宿主-寄生虫相互作用。

膜联蛋白在人兽共患蠕虫病感染中作用机制的研究进展

Research Progress on Mechanism of Annexin in Zoonotic Helminth Diseases

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