Abstract: The paper introduced the way and method for utilizing Oryza Officinalis to breed a new hybrid rice restorer line directly by crossbreeding. The method was being made use of five different Oryza sativa with different characters, one of which is Oryza Officinalis that as a main parent used to cross with the others, and adopted an idea of “big population and abounding generations” for selection. Through this way, the author had made good use of the strong resistance, good compatibility and good rice quality of Oryza Officinalis; and got an excellent hybrid rice restorer line: Ce253 successfully, also got a series good hybrid rice breeds that have high yield, good compatibility and good agronomic characters, using Ce253 as a parent. It was the first time for using the Oryza Officinalis breeding an excellent hybrid rice restorer line directly, through the Oryza Officinalis cell nucleus gene. It developed a new successful-way for hybrid rice breeding. The paper also introduced the application and social benefits of the Ce253 and its hybrid breeds.