Abstract: The experiment adopt five weeks old healthy Kunbai mice as experimental animal.The mice were fed the common fodder and given plumbum(Pb)，vitamin C(Vc) and the mixtures of these two things.The dosage of the Vc is 200mg/kg .The dosage of Pb had four grads 1.2g/L、0.4g/L、0.13g/L、0.043g/L .The experiment lasts three weeks.Then detect the Pb MDA content and SOD POD CAT activity .The results show that the plumbum accumulated in liver largely,and the content of MDA increased.The activity of SOD in every group lowered significantly (P<0.05) compared with the control group,and increased with the fall of Pb’s concentration. We mensurated the activity of CAT,the mensuration displayed that the Pb1、Pb2 group had significant difference（p<0.05）to compared with the control group,and the Pb3 had significant difference(p<0.01). At the same time, except the Vc+Pb4 group had no significant difference(p>0.05),the rest group had significant difference (p<0.05)compared with their corresponding groups which only add Pb. The mensuration of POD activity showed : compared with the control group,the Vc group had significant difference(p<0.01),the Pb1、Pb3 group had significant difference（p<0.05）.Compared with their corresponding groups which only add Pb,the Vc+Pb1 group had no significant difference（p>0.05）, the rest Vc+Pb group compared with their corresponding groups which only add Pb had significant difference(p<0.01). The the result of experiment indicated that the plumbum can intensify the lipid peroxidation,but Vc can lighten the scathe caused by lipid peroxidation.