Abstract: College-graduate "village officials" is an important part of the construction of a new socialist countryside, development of modern agriculture and driving rural poverty. The article outlined the practical significance of college-graduate "village officials" entrepreneurship by Jiangsu Academy of Agricultural Sciences as an example. It analyzed the main problems of affecting college-graduate "village officials" entrepreneurship. These problems include the lack of agricultural knowledge and low active to projects of college-graduate "Village Officials", loopholes in management of Jiangsu Academy of Agricultural Sciences, etc. The article proposed the helping measures through arrangements venture capital, formulation projects and strengthens training. It provided examples of reference for the authorities to build lasting effect mechanism about college-graduate "village officials".