Abstract: To establish a rapid detection method of sulfonamides residues in aquatic products. Application the GICA technology developed a rapid detection test strip of sulfonamides in aquatic products. Goat anti-mouse IgG, Immunogen antigen (SDL-HSA) and gold labeled monoclonal antibody three after repeated testing optimized to suitable concentration and spray volume coated to nitrocellulose (NC) membrane and micropore. The test indicated that: the lowest detection limits of SD, ST, SMZ, SMM, SM2, SQX, SMP, SMD of eight kinds of Sulfonamides are 5, 5, 10, 40, 45, 50, 100, 100μg/kg. No cross-reactivity with other veterinary drugs such as streptomycin, tetracycline, chloramphenicol, clenbuterol, ciprofloxacin. The result showed that the test device has high sensitivity and specificity and was easy to operate. It could be the most rapid and convenient means for detection of sulfonamides in the aquatic products.